TABLE 4.
Effect of single administration of FK463 on fungal titers in the kidneys of mice in the disseminated C. albicans infection model
| Compound | Dose (mg/kg) | Viable count (log CFU/kidneys)a |
|---|---|---|
| Control | ||
| 0 h | 3.35 ± 0.10 | |
| 24 h | 4.93 ± 0.09 | |
| FK463 | 1 | 1.73 ± 0.17* |
| 0.5 | 2.62 ± 0.34* | |
| 0.25 | 4.20 ± 0.12 | |
| AMPH-B | 1 | 2.35 ± 0.16* |
| 0.5 | 2.98 ± 0.20* | |
| 0.25 | 3.50 ± 0.26 | |
| FLCZ | 4 | 3.86 ± 0.13 |
a
Mean log10 CFU ± standard deviation per paired kidneys at 24 h after infection. *, significantly different from the control at 0 h (P < 0.01) by one-way layout analysis of variance and the Dunnet t test.