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. 2022 Apr;74(2):373–386. doi: 10.1124/pharmrev.120.000256

Fig. 4.

Fig. 4

Overall selection of T cells associated with depression. Glucocorticoid treatment and microbiota alterations in depression have been associated with a shift toward Th17 cells. Catecholamines seem to favor Th2 cells. However, catecholamines promote T helper cell activation, whereas they block leukocyte migration. Antidepressant treatments in contrast seem to reduce T helper cells in a nonspecific manner and favor regulatory T cells.