Fig. 4.
Overall selection of T cells associated with depression. Glucocorticoid treatment and microbiota alterations in depression have been associated with a shift toward Th17 cells. Catecholamines seem to favor Th2 cells. However, catecholamines promote T helper cell activation, whereas they block leukocyte migration. Antidepressant treatments in contrast seem to reduce T helper cells in a nonspecific manner and favor regulatory T cells.