Table 2.
circRNA as suppressor in HCC
| circRNA | Source of sample | Expression | Function | Mechanism/pathway | Refs. |
|---|---|---|---|---|---|
| circARSP91 |
Tissues Cell lines Animal |
Downregulation | Growth (−) |
AR/ADAR1/Cir ARSP91 |
[112] |
| circRNA7 | Cell lines | Downregulation |
Migration (−) Invasion (−) Vasculogenic mimicry (−) |
AR/circRNA7/miRNA7-5p/VE-Cadherin/Notch4 | [111] |
| circMTO1 |
Tissues Cell lines Animal |
Downregulation |
Proliferation (−) Invasion (−) Growth (−) Apoptosis (+) |
circMTO1/miR9/p21 | [101] |
| circRNA-5692 |
Tissues Cell lines Animal |
Downregulation |
Proliferation (−) Invasion (−) EMT (−) Growth (−) Apoptosis (+) |
circRNA-5692/miR-328-5p/DAB2IP | [104] |
| circSMAD2 |
Tissues Cell lines |
Downregulation |
Migration (−) Invasion (−) EMT (−) |
circSMAD2/miR-629 | [103] |
| circADAMTS13 |
Tissues Cell lines |
Downregulation |
Proliferation (−) Apoptosis (+) |
circADAMTS13/miR-484 | [102] |
| hsa_circ_0079929 |
Tissues Cell lines Animal |
Downregulation |
Proliferation (−) Growth (−) |
PI3K/AKT/mTOR | [108] |
| circ_0004913 |
Tissues Cell lines Animal |
Downregulation |
Proliferation (−) Migration (−) Invasion (−) Growth (−) |
circ_000491/miR-184/HAMP/JAK2/STAT3/AKT | [109] |
| hsa_circ_0004018 |
Tissues Cell lines Animal |
Downregulation |
Proliferation (−) Migration (−) Growth (−) Apoptosis (+) |
hsa_circ_0004018/miR-626/DKK3 | [110] |
| hsa_circ_0005986 |
Tissues Cell lines |
Downregulation | Proliferation (−) | hsa_circ_0005986/miR-129-5p/Notch1 | [105] |
| circC3P1 |
Tissues Cell lines Animal |
Downregulation |
Proliferation (−) Migration (−) Invasion (−) Growth (−) |
circC3P1/miR4641/PCK1 | [106] |
| circSETD3 |
Tissues Cell lines Animal |
Downregulation |
Growth (−) Proliferation (−) |
circSETD3/miR421/MAPK14 | [107] |
Refs references; ( +) promoting effects; ( −) inhibiting effects