Table 1.
Patient no. (set of twins no.) | Isolate no. | Date (mo-yr) | Ward | Sample type | Species | Antibiotic resistance | Reistance genes | WGS cluster type | RAPD type | PFGE type | MLST | FTIR type |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ID01 | 10,457 | Sep-17 | NICU | perianal | E. hormaechei subsp. steigerwaltii | CTX-R, ERT-I | blaACT-15, fosA | 1 | 1 | A | 50 | A |
ID01 | 10,502 | Sep-17 | NICU | oropharyngeal | E. hormaechei subsp. steigerwaltii | blaACT-15, fosA | 1 | 1 | A | 50 | A | |
ID02 (1) | 10,501 | Sep-17 | NICU | nasal/oropharyngeal | E. hormaechei subsp. steigerwaltii | blaACT-15, fosA | 1 | 1 | A | 50 | A | |
ID03 | 10,500 | Sep-17 | NICU | nasal/oropharyngeal | E. hormaechei subsp. steigerwaltii | GEN-R | blaACT-15, fosA | 1 | 1 | A | 50 | A |
ID03 | 10,504 | Sep-17 | NICU | nasal/oropharyngeal | E. hormaechei subsp. steigerwaltii | CTX-R | blaACT-15, fosA | 1 | 1 | n.d | 50 | A |
ID05 | 10,505 | Sep-17 | NICU | perianal | E. hormaechei subsp. steigerwaltii | CTX-R, ERT-I, GEN-R | blaACT-15, fosA | 1 | 1 | n.d | 50 | B |
ID05 | 10,481 | Sep-17 | NICU | nasal/oropharyngeal | E. hormaechei subsp. steigerwaltii | CTX-R, ERT-R | blaACT-15, fosA | 1 | 1 | A | 50 | A |
ID06 (1) | 10,503 | Sep-17 | NICU | oropharyngeal | E. hormaechei subsp. steigerwaltii | GEN-R | blaACT-15, fosA | 1 | 1 | A | 50 | A |
ID06 (1) | 10,668 | Oct-17 | PICU | nasal/oropharyngeal | E. hormaechei subsp. steigerwaltii | CTX-R | blaACT-15, fosA | 1 | 1 | n.d | 50 | A |
ID07 | 10,593 | Oct-17 | PICU | nasal/oropharyngeal | E. hormaechei subsp. steigerwaltii | GEN-R | blaACT-15, fosA | 1 | 1 | A | 50 | A |
ID07 | 10,721 | Oct-17 | PICU | nasal/oropharyngeal | E. hormaechei subsp. steigerwaltii | blaACT-15, fosA | 1 | 1 | n.d | 50 | A | |
ID15 | 10,832 | Nov-17 | PICU | nasal/oropharyngeal | E. hormaechei subsp. steigerwaltii | CTX-R, ERT-R | blaACT-15, fosA | 1 | 1 | A | 50 | A |
ID16 | 10,833 | Nov-17 | PICU | nasal/oropharyngeal | E. hormaechei subsp. steigerwaltii | blaACT-15, fosA | 1 | 1 | A | 50 | A | |
ID04 | 10,506 | Sep-17 | PICU | central line | E. hormaechei subsp. hoffmannii | blaACT-14, fosA | 2 | 2 | B | 168 | A | |
ID08 | 10,539 | Oct-17 | NICU | tracheal secretions | E. hormaechei subsp. hoffmannii | blaACT-14, fosA | 2 | 2 | B | 168 | A | |
ID10 | 10,720 | Oct-17 | NICU | oropharyngeal | E. hormaechei subsp. hoffmannii | blaACT-14, fosA | 2 | 2 | B | 168 | A | |
ID12 | 10,722 | Nov-17 | NICU | perianal | E. hormaechei subsp. hoffmannii | blaACT-14, fosA | 2 | 2 | B | 168 | A | |
ID14 | 10,834 | Nov-17 | NICU | oropharyngeal | E. hormaechei subsp. hoffmannii | blaACT-14, fosA | 2 | 2 | B | 168 | A | |
ID17 | 10,886 | Dec-17 | NICU | perianal | E. hormaechei subsp. hoffmannii | blaACT-14, fosA | 2 | 2 | B | 168 | A | |
ID18 (2) | 10,909 | Dec-17 | PICU | perianal | E. hormaechei subsp. hoffmannii | CTX-R | blaACT-14, fosA | 2 | 2 | B | 168 | A |
ID19 (2) | 10,940 | Dec-17 | NW | perianal | E. hormaechei subsp. hoffmannii | CTX-R, ERT-R | blaACT-14, fosA | 2 | 2 | B | 168 | A |
ID21 (3) | 10,995 | Dec-17 | NICU | perianal | E. hormaechei subsp. hoffmannii | blaACT-14, fosA | 2 | 2 | n.d | 168 | A | |
ID22 (3) | 10,994 | Jan-18 | NICU | oropharyngeal | E. hormaechei subsp. hoffmannii | CTX-R | blaACT-14, fosA | 2 | 2 | B | 168 | A |
ID13 | 10,749 | Nov-17 | PICU | tracheal secretions | E. hormaechei subsp. oharae | blaACT-7 | 3 | 3 | C | 1086 | H | |
ID13 | 11,155 | Feb-18 | PICU | tracheal secretions | E. hormaechei subsp. oharae | CTX-R, ERT-R, IPM-I, MEM-R | blaACT-7 | 3 | 3 | C | 1086 | E |
ID20 | 10,938 | Dec-17 | PICU | perianal | E. hormaechei subsp. steigerwaltii | CTX-R | blaACT-7, fosA | 4 | 4 | D | 116 | C |
ID24 | 11,062 | Jan-18 | PICU | eye | E. hormaechei subsp. hoffmannii | blaACT-14, fosA | 5 | 5 | E | 104 | D | |
ID24 | 11,115 | Jan-18 | PICU | perianal | E. hormaechei subsp. hoffmannii | CTX-R | blaACT-14, fosA | 5 | 5 | E | 104 | D |
ID26 | 11,183 | Feb-18 | NICU | perianal | E. cloacae subsp. cloacae | blaCMH-3, fosA | 6 | 6 | F | 477 | F | |
ID27 (4) | 11,227 | Feb-18 | PICU | nasal/oropharyngeal | E. hormaechei subsp. hoffmannii | blaACT-14, fosA | 7 | 7 | G | 278 | G | |
ID27 (4) | 12,015 | Aug-18 | PICU | groin | E. hormaechei subsp. hoffmannii | CTX-R, CIP-I, MXF-R | blaACT-14, fosA | 7 | 7 | G | 278 | B |
ID29 (4) | 11,229 | Feb-18 | PICU | eye | E. hormaechei subsp. hoffmannii | blaACT-14, fosA | 7 | 7 | G | 278 | G |
Antibiotic resistance (I, intermediate; R, resistant): CTX, cefotaxime; ERT, ertapenem; IPM, imipenem; MEM, meropenem; GEN, gentamicin; CIP, ciprofloxacin; MXF, moxifloxacin; Wards: NICU, neonatal intensive care unit; PICU, paediatric (and neonatal) intensive care unit; NW, neonatal ward; n.d., not determined