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. 2022 Apr 1;23:245. doi: 10.1186/s13063-022-06161-8
Stage 1 Stage 2 Stage 3
Cumulative sample size (control): 41 82 123
Cumulative sample size (treatment): 41 82 123
Maximum total sample size: 246
Upper bound 2.13 1.89 1.85
Lower bound 0.00 1.13 1.85
p-value for H1 ((stopping for) success) 0.018 0.031 0.033
p-value for H0 (stopping for a lack of efficacy) 0.500 0.130
Continue as planned at stage 1: 0.500 > p >  0.018
Continue as planned at stage 2: 0.130 > p >  0.031

The calculation was done with the R package MAMS