Table 1.
Related noncoding RNAs in gastric cancer of this review
| Type of ncRNAs | Expression | Putative roles | Pathway | Targets | Ref |
|---|---|---|---|---|---|
| lncRNAs | |||||
| LINC00152 | Upregulated | Promote proliferation and colony formation | EMT | E-cadherin | [39] |
| HOTAIR | Upregulated | Lmphatic metastasis | H3K27 methylation | H3K27 | [53] |
| DKFZP434K028, RPL34-AS1 |
Downregulated | Potential biomarker | Unknown | MYRF | [47] |
| LINC01133 | Downregulated | EMT/ metastasis | Wnt/β-catenin | miR-106a-3p/ APC |
[54] |
| XLOC_006753 | Upregulated | Promote drug resistance | mTOR/PI3K/AKT signaling | Unknown | [55] |
| lncR-D63785 | Downregulated | Promote drug resistance | mTOR/PI3K/AKT signaling | miR-422/MEF2D | [56] |
| ZFAS1 | Upregulated | Promote proliferation and migration | EMT | KLF2 and NKD2 | [57] |
| Lnc-GNAQ-6:1 | Downregulated | Potential biomarker | Unknown | Unknown | [58] |
| lncSLC2A12-10:1 | Upregulated | Potential biomarker |
Unknown | Unknown | [59] |
| LINC00483 | Upregulated | Promote invasion and migration |
Unknown | miR-490-3p/MAPK1 | [60] |
| lncRNA HCP5 | Upregulated | Promote proliferation, invasion, and migration | Unknown | miR-299-3p/SMAD5 | [62] |
| LINC00240 | Upregulated | Promote proliferation and migration | Unknown | miR-338-5p/METTL3 | [63] |
| LINC01320 | Upregulated | Promote aggressive phenotype | Unknown | miR-495-5p/RAB19 | [64] |
| CERS6-AS1 | Upregulated | Promote proliferation, migration and invasion | Unknown | Unknown | [65] |
| LINC00511 | Upregulated | Promote proliferation and migration | Unknown | microRNA-625-5p/STAT3 | [66] |
| PCED1B-AS1 | Upregulated | Promote proliferation, migration, invasion and EMT | Unknown | microRNA-215-3p/C-X-C motif chemokine receptor 1 | [67] |
| LINC00649 | Upregulated | Promote proliferation, migration and EMT | YAP1/Hippo pathway | miR-16-5p | [68] |
| NR2F1-AS1 | Upregulated | Promote proliferation, invasion and migration | Unknown | SPI1/ST8SIA1 | [69] |
| AL139002.1 | Upregulated | Promote proliferation, migration, invasion, and EMT | Unknown | microRNA-490-3p Hepatitis A Virus Cellular Receptor 1 | [70] |
| LINC00265 | Upregulated | Promote proliferation | Unknown | microRNA-144-3p/Chromobox 4 | [71] |
| MYLK-AS1 | Upregulated | Promote proliferation, migration, and invasion | Unknown | LATS2 | [72] |
| BC031243 | Upregulated | CRS + HIPEC | Unknown | Unknown | [107] |
| RP11-356I2.2 | Upregulated | CRS + HIPEC | Unknown | Unknown | [107] |
| miRNAs | |||||
| miR-199a-3p | Upregulated | Promote invasion and migration | Unknown | ETNK1, ZHX1 | [45] |
| miR-1, miR-34 | Downregulated | Inhibit drug resistance | Unknown | Sorcin | [46] |
| miR-100-3p | Downregulated | Inhibit proliferation and apoptosis | Bax/Bcl2/Caspase3 | BMPR2 | [75] |
| miR-221 | Upregulated | lymph node metastasis | p-JAK2, p-STAT3 | SOCS3 | [76] |
| miR-423-5p | Upregulated | lymph node metastasis | Unknown | SUFU | [77] |
| miR-3189-3p | Downregulated | CRS + HIPEC | Unknown | CFL2 | [106] |
| miR-1825 | Downregulated | CRS + HIPEC | Unknown | Unknown | [106] |
| miR-32-3p, miR-3149, miR-4297 | Upregulated | CRS + HIPEC | Unknown | Unknown | [106] |
| miR-1299 | Upregulated | CRS + HIPEC | Unknown | ETS1 | [106] |
| miR-218 | Upregulated | CRS + HIPEC | SMO signaling | Gli2 | [107] |
| miR-8-3p | Upregulated | HIPEC | AMPK signaling | PPP2R5B | [110] |
| miR-23a | Downregulated | Heat-stressed | Unknown | NOXA | [112] |
| miR-10b | Downregulated | Hyperthermia | Unknown | Hoxd10 | [113] |
| miR-15b | Downregulated | Hyperthermia | DYNLT1/Caspase-3/Caspase-9 signaling | DYNLT1 | [113] |
| miR-106a | Upregulated | Promote growth | Unknown | Smad7 | [78] |
| miR-425 | Upregulated | Promote cell viability, migration, and invasion | Unknown | Dickkopf-related protein-3 | [79] |
| miR −1269b | Downregulated | Inhibit proliferation, migration, and invasion | Unknown | METTL3 | [80] |
| miR-130a-3p | Upregulated | Promote proliferation, migration, and invasion | Unknown | GCNT4/TGF-beta1/SMAD3 | [81] |
| circRNAs | |||||
| ciRS-7 | Upregulated | Inhibit the invasion | PTEN/PI3K/AKT Signaling | miR-7 | [48] |
| circ-PVT1 | Upregulated | Promote drug resistance | Unknown | miR-124/ZEB1 | [84] |
| circ-MTHFD2 | Upregulated | Promote drug resistance | Unknown | miR-124 | [85] |
| circ-OXCT1 | Downregulated | Suppress EMT progress | Unknown | miR-136/SMAD4 | [86] |
| circCCDC9 | Downregulated | Inhibit the proliferation, migration and invasion | Unknown | miR-6792-3p/CAV1 | [87] |
| circ-RanGAP1 | Upregulated | promotes GC progression | Unknown | miR-877-3p/VEGFA | [88] |
| circSHKBP1 | Upregulated | Promote proliferation, invasion and migration |
miR-582-3p/HUR/VEGF | miR-582-3p | [89] |
| circRNA_102231 | Upregulated | Promote proliferation and invasion | Unknown | IRTKS | [90] |
| hsa_circ_0000751 | Downregulated | Inhibit progression, migration, and invasion | Unknown | miR-488/UQCRC2 | [91] |
| circPRKDC | Upregulated | Promote cell viability, metastasis, and EMT |
Unknown | IRS2/microRNA-493-5p | [92] |
| circ-HN1 | Upregulated | Promote proliferation, migration, and invasion |
miR-485-5p/GSK3A pathway | Unknown | [93] |
| hsa_circ_0000117 | Upregulated | Promote proliferation and invasion | Unknown | microRNA-337-3p/signal transducer and activator of transcription 3 axis | [94] |
| circCOL6A3_030 | Upregulated | Promote migration |
Unknown | Unknown | [95] |
| circ0005654 | Upregulated | Promote proliferation, migration and invasion | Unknown | miR-363/sp1/myc/Wnt/β-catenin axis | [96] |