Table 1.

Characteristics of studies included in this meta-analysis

First author	Year	Region	MicroRNAs	Regulation mode	Specimen	Internal reference types in qRT-PCR	Sample size				Diagnostic power			Ref.
							Case	Number	Control	Number	SEN (%)	SPE (%)	AUC
El-Garem H	2014	Egypt	miR-211	Downregulated	Serum	SNORD68	HCC	30	LC + HC	60	87	40	0.655	[9]
El-Abd NE	2015	Egypt	miR-16	Downregulated	Serum	RNU48	HCC	40	CHC	40	57.5	70	0.638	[10]
Motawi TK	2015	Egypt	miR-19a	Downregulated	Serum	SNORD68	HCC	112	LC	50	85.7	75	0.816	[13]
Motawi TK	2015	Egypt	miR-296	Upregulated	Serum	SNORD68	HCC	112	LC	50	76.9	56.5	0.666	[13]
Motawi TK	2015	Egypt	miR-195	Downregulated	Serum	SNORD68	HCC	112	LC	50	66.7	70.8	0.665	[13]
Motawi TK	2015	Egypt	miR-192	Upregulated	Serum	SNORD68	HCC	112	LC	50	78.6	62.5	0.730	[13]
Motawi TK	2015	Egypt	miR-34a	Upregulated	Serum	SNORD68	HCC	112	LC	50	51.9	82.6	0.663	[13]
Motawi TK	2015	Egypt	miR-146a	Upregulated	Serum	SNORD68	HCC	112	LC	50	96.4	73.9	0.880	[13]
Amr KS	2017	Egypt	miR-122	Downregulated	Plasma	RUN6B	HCC	40	CHC	40	87.5	97.5	NA	[11]
Amr KS	2017	Egypt	miR-244	Upregulated	Plasma	RUN6B	HCC	40	CHC	40	87.5	97	NA	[11]
Shaker O	2017	Egypt	miR-101-1	Downregulated	Serum	SNORD68	HCC	37	LC + HC	78	73	71	0.763	[14]
Shaker O	2017	Egypt	miR-221	Upregulated	Serum	SNORD68	HCC	37	LC + HC	78	56.8	73.9	0.673	[14]
Elemeery MN	2017	Egypt	miR-214-5P	Downregulated	Serum	SNORD68	HCC	224	CHC	250	92.2	75.5	0.842	[15]
Elemeery MN	2017	Egypt	miR-494	Upregulated	Serum	SNORD68	HCC	224	CHC	250	77	56	0.631	[15]
Elemeery MN	2017	Egypt	miR-138b	Downregulated	Serum	SNORD68	HCC	224	CHC	250	68.2	58.2	0.642	[15]
Elemeery MN	2017	Egypt	miR-125b	Downregulated	Serum	SNORD68	HCC	224	CHC	250	92.6	55.4	0.769	[15]
Elemeery MN	2017	Egypt	miR-1269	Upregulated	Serum	SNORD68	HCC	224	CHC	250	78.6	59.8	0.691	[15]
Elemeery MN	2017	Egypt	miR-145	Downregulated	Serum	SNORD68	HCC	224	CHC	250	81.5	51.5	0.624	[15]
Elemeery MN	2017	Egypt	miR-375	Downregulated	Serum	SNORD68	HCC	224	CHC	250	96.4	69.3	0.811	[15]
Elemeery MN	2017	Egypt	miRNA clusters(4)	NA	Serum	SNORD68	HCC	224	Fibrosis	150	96,7	94.3	0.945	[15]
Elemeery MN	2017	Egypt	miRNA clusters(4)	NA	Serum	SNORD68	HCC	224	Fibrosis	100	98.7	98.3	0.990	[15]
Shaheen NMH	2018	Egypt	miR-182	Downregulated	Serum	Cel-miR-39	HCC	40	CHC	20	72.5	65	0.675	[16]
Shaheen NMH	2018	Egypt	miR-150	Downregulated	Serum	Cel-miR-39	HCC	40	CHC	20	67.5	70	0.704	[16]
Rashad NM	2018	Egypt	miR-27a	Upregulated	Serum	SNORD68	HCC	51	LC	39	96.7	71.7	0.897	[17]
Rashad NM	2018	Egypt	miR-18b	Upregulated	Serum	SNORD68	HCC	51	LC	39	75.6	46.7	0.732	[17]
Rashad NM	2018	Egypt	miRNA clusters(2)	Upregulated	Serum	SNORD68	HCC	51	LC	39	91.1	71.7	0.821	[17]
El-Hamouly MS	2019	Egypt	miR-301	Upregulated	Plasma	U6	HCC	42	CHC	48	78.6	89.6	0.890	[18]
Ali LH	2019	Egypt	miR-215	Upregulated	Serum	SNORD68	HCC	60	LC	60	97.1	91	0.997	[19]
Shehab-Eldeen S	2019	Egypt	miR-122	Downregulated	Plasma	U6	HCC	20	CHC	20	95	81	0.930	[20]
Shehab-Eldeen S	2019	Egypt	miR-224	Upregulated	Plasma	U6	HCC	20	CHC	20	85	79	0.770	[20]
Sun Q	2019	China	miR-331-3p	Upregulated	Serum	Cel-miR-39	HCC	40	CHC	106	62.5	74.5	0.748	[21]
Sun Q	2019	China	miR-23b-3p	Downregulated	Serum	Cel-miR-39	HCC	40	CHC	106	85.8	65	0.806	[21]
Sun Q	2019	China	miR-331-3p	Upregulated	Serum	Cel-miR-39	HCC	40	LC	47	75	85.1	0.832	[21]
Sun Q	2019	China	miR-23b-3p	Downregulated	Serum	Cel-miR-39	HCC	40	LC	47	85.1	65	0.796	[21]
Oura K	2019	Japan	miR-125a-5p	Upregulated	Serum	Cel-miR-39	HCC	20	LC + CHC	20	80	100	0.980	[22]
Weis A	2019	Australia	miRNA clusters(3)	NA	Serum	SNORD68	HCC	20	CHC	20	80	95	0.940	[23]
Fatma A	2019	Egypt	miR-19a	Upregulated	Serum	SNORD68	HCC	40	LC + CHC	40	60	67.5	0.616	[24]
Fatma A	2019	Egypt	miR-223	Downregulated	Serum	SNORD68	HCC	40	LC + CHC	40	60	95	0.816	[24]
Aly DM	2020	Egypt	miR-let-7a-1	Downregulated	Serum	SNORD68	HCC	40	LC	20	70	82.5	0.740	[25]

qRT-PCR quantitative real-time reverse transcription PCR, HCC hepatocellular carcinoma, LC liver cirrhosis, CHC chronic hepatitis C, SEN sensitivity, SPE specificity, AUC area under the curve, Ref., references