Table 2.
The meta-regression analysis of variable parameters
| Parameters | Sensitivity | Specificity | Joint model | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| estimate (95% CI) | Coef | Z | P >|z| | estimate (95% CI) | Coef | Z | P >|z| | I-squared (95% CI) | LRTChi | P value | |
| Region | 0.75 (0.45–0.92) | 1.09 | − 0.77 | 0.44 | 0.92 (0.74–0.98) | 2.43 | 1.66 | 0.10 | 61.57 (13.37–100.00) | 5.2 | 0.07 |
| Specimen types | 0.88 (0.71–0.96) | 2.00 | 0.77 | 0.51 | 0.93 (0.82–0.97) | 2.57 | 2.47 | 0.01 | 72.39 (38.81–100.00) | 7.24 | 0.03 |
| Regulation mode | 0.88 (0.81–0.93) | 2.02 | 1.17 | 0.24 | 0.87 (0.79–0.92) | 1.90 | 2.21 | 0.03 | 77.68 (51.46–100.00) | 8.96 | 0.01 |
| Internal reference types | 0.78 (0.63–0.89) | 1.28 | − 0.77 | 0.44 | 0.85 (0.74–0.92) | 1.77 | 1.35 | 0.18 | 59.09 (7.72–100.00) | 4.89 | 0.09 |
| miRNAs profiling | 0.96 (0.89–0.98) | 3.11 | 2.70 | 0.01 | 0.94 (0.84–0.98) | 2.70 | 2.73 | 0.01 | 85.14 (69.07–100.00) | 13.46 | < 0.01 |
| Sample size | 0.88 (0.78–0.93) | 1.95 | 0.90 | 0.37 | 0.69 (0.53–0.81) | 0.80 | − 1.33 | 0.26 | 52.19 (0.00–100.00) | 4.18 | 0.12 |
| Control groups | 0.86 (0.79–0.91) | 1.78 | 0.54 | 0.59 | 0.82 (0.75–0.88) | 1.54 | 1.25 | 0.21 | 49.72 (0.00–100.00) | 3.98 | 0.14 |
miRNAs microRNAs, 95% CI 95% confidence intervals, Coef. coefficient