Figure 1.

Model of plectin-mediated cytoskeletal crosstalk at the cell–cell interface. Cells within epithelial tissues are in a state of isometric tension, with actomyosin-generated forces being balanced by the resistive capacity of the IF network. The IF network consists of radial spokes extending from the nucleus and anchored at desmosomes. These spokes are interconnected by a subplasmalemmal circumferential IF rim that is coupled to the cortical actomyosin machinery through plectin, providing mechanical resistance along the plasma membrane. Plectin deficiency results in a loss of the circumferential IF rim and redistribution of cytoskeletal forces. Absence of the IF rim is associated with bundling of IF spokes, increased actomyosin contractility, and aberrant tensile loading of desmosomes.