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miR-761 directly targets IRS1. (a) The binding sites of miR-761 within the IRS1 3ʹ-UTR. (b) The luciferase activity of wt-IRS1 or mut-IRS1 was measured after treatment with the miR-761/NC mimic. (c, d) The IRS1 levels were assessed in miR-761-overexpressing OS cells. **P < 0.01.
