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. 2022 Jan 17;13(2):3108–3121. doi: 10.1080/21655979.2022.2025701

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Knockdown of LINC01273 reduces sorafenib resistance. A. The flowchart of constructing sorafenib resistant cell lines. B. CCK-8 testing cell viability of the indicated cells after treatment with different concentrations of sorafenib. C. Western blot testing the level of ABCG2 expression in the indicated cells. D. qRT-PCR assay analyzing the expression of LINC01273 in sorafenib resistant cell lines. E. qRT-PCR verifying the silence efficiency of these shRNAs. F-H. CCK-8, colony formation and EdU assays detecting cell viability, colony and DNA synthesis rate in LINC01273-silenced sorafenib resistant cell lines. Scale bar = 50 μM, **P < 0.01.