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. 2022 Jan 17;13(2):3108–3121. doi: 10.1080/21655979.2022.2025701

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — LINC01273 regulates METTL3 expression. A. Detection of total m⁶A levels in the indicated cell lines. B. qRT-PCR analysis of the m⁶A-related gene levels in LINC01273-silenced sorafenib resistant cell lines. C. Western blot testing METTL3 protein expression in LINC01273-silenced sorafenib resistant cell lines. D, E. qRT-PCR testing METTL3 expression in sorafenib resistant HCC tissues, followed by analysis of its correlation with LINC01273. F, G. Detection of cell viability and DNA synthesis rate in LINC01273-silenced sorafenib resistant cell lines with METTL3 silencing. *P < 0.05,**P < 0.01.