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. 2022 Jan 17;13(2):3108–3121. doi: 10.1080/21655979.2022.2025701

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — LINC01273 is modified by m⁶A induced by METTL3. A. The effect of METTL3 overexpression on LINC01273 expression. B, C. The m⁶A motif on LINC01273 was mutated and inserted into psiCHECK-2 vector, followed by luciferase reporter assay in cells transfected with METTL3 plasmid. D. qRT-PCR testing LINC01273 level in METTL3-overexpressed cells after treatment with Actinomycin D at the different time. E. MeRIP assay analyzing m⁶A enrichment on LINC01273. F. RIP assay testing the enrichment of LINC01273 by YTHDF2. G. qRT-PCR analysis of LINC01273 expression in sorafenib resistant cell lines transfected with YTHDF2 siRNA. **P < 0.01.