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. 2022 Jan 26;13(2):3810–3826. doi: 10.1080/21655979.2022.2031420

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — The expression of miR-656-3p is downregulated in CRC tissues. (a) Abundance analysis of miR-656-3p in 119 tumor and their paired cancer-free tissues. (b) The distribution analysis of the miR-656-3p expression in tumor and in adjacent tissues among 119 pairs of specimens. (c) Abundance analysis of miR-656-3p in cancer tissues with or without lymphatic metastasis. miR-656-3p was upregulated expression in colorectal cancer tissues without lymphatic metastasis. (d) miR-656-3p expression in NCM460, SW480, RKO, DLD1, SW48, HCT116, LOVO, HT29, HCT8, and SW620 cells. U6 was employed as an internal reference. (e) The level of miR-656-3p was measured in the normal tissues and without LN metastasis tissues. **p < 0.01, ***p < 0.001 compared with group NCM460.