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. 2022 Jan 26;13(2):3810–3826. doi: 10.1080/21655979.2022.2031420

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — miR-656-3p directly binds to 3’ UTR of SGPP1 mRNA. (a) Potential binding sites between miR-656-3p and 3’ UTR of SGPP1 mRNA. (b–c) Dual fluorescein reporter gene analysis of the binding sites between miR-656-3p, wild type, and mutation of the 3’ UTR in SGPP1 mRNA. (d) Protein and mRNA analysis of the SGPP1 knockdown effect in SW480 cells. (e) Cell survival analysis of the chemotherapy drugs (5-FU) in miR-656-3p and SGPP1 knockdown-treated SW480 cells. ***p < 0.001 compared with group LV-mNC or LV-INC.