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. 2022 Feb 13;13(2):2552–2565. doi: 10.1080/21655979.2021.2018538

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Expression of LINC00525 in colorectal cancer cells.

(A) Results of qPCR indicated that LINC0052 was highly expressed in colorectal cancer cells (SW480, HCT116, HT29, SW620, SW1116 and LoVo) which was compared with normal colonic epithelial cells (NCM-460). Data shown are mean ±SD (n = 3). *** P < 0.001 vs NCM-460 group.(B) LINC00525-specific small interfering RNA (si-525-1, si-525-2 and si-525-3) was transferred into colorectal cancer cells to knock down the expression of LINC00525, and meaningless small interfering RNA (si-NC) was used as a negative control. And qPCR analysis of the indicated LINC00525 levels significantly decreased after being transferred into si-525. Data shown are mean ±SD (n = 3). ### P < 0.001 vs si-NC group.(C) Results of FISH staining not only showed that LINC00525 was expressed in the cytoplasm of colorectal cancer cells, but also confirmed that si-525 significantly knocks down the expression of LINC00525.