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Synergistic inhibition effects of Rhein and RAD001 on MGC-803 cell proliferation in vivo. A-C. Mice received Rhein (60 mg/kg) and RAD001 (5 mg/kg) by oral administration. Tumor weight and tumor volume were detected at each group. D. The expressions of PI3K/AKT/mTOR pathway proteins were detected using Western blotting. E. Immunohistochemical (IHC) staining of tumor cell proliferation marker Ki-67 expression. *p < 0.05.
