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. 2022 Feb 24;13(3):6208–6221. doi: 10.1080/21655979.2022.2037249

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — miR-23a-3p targeted to DNM3 with negative regulation and the inhibition of DNM3 expedited cancer cells proliferation, migration and invasion. (a) Bioinformatics analysis indicated there were complementary sequences between DNM3 and miR-23a-3p. The direct relationship between them was provided by the dual luciferase reporter assay. (b) DNM3 was downregulated confirmed via qRT-PCR in 60 pairs of cholangiocarcinoma tissues as well as normal tissues. (c) MiR-23a-3p was negatively correlated with DNM3 expression. (d) Western blot observed the suppressed DNM3 level in 8 pairs of cancer tissues. (e) The decreasing DNM3 level was found after transfection with miR-23a-3p inhibitor as well as si-DNM3. (f-g) CCK-8 as well as colony formation assays displayed the enhanced proliferation level of cells after silencing DNM3. (h) Tranwell assays exhibited that knockdown DNM3 could promote cell migration and invasion.