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. 2022 Jan 16;13(2):2296–2307. doi: 10.1080/21655979.2021.2024389

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — ADORA2A-AS1 acts as an endogenous sponge for miR-665. (a) The predicted binding sequence of miR-665 on ADORA2A-AS1, and the mutants of ADORA2A-AS1 and miR-665. (b) The relative luciferase activity in HEK 293 T cells cotransfected with ADORA2A-AS1-WT or ADORA2A-AS1-MUT reporter and miR-665 mimics or mimics control. RIP assay was performed in K562 (c), and KCL22 (d) cell extracts to examine miR-665 endogenously associated with ADORA2A-AS1. qRT-PCR was used to examine the expression of miR-665 in K562 (e) and KCL22 (f) cells transfected with si-ADORA2A-AS1 or si-control. (g) The expression of miR-665 in healthy donors and CML patients. **P < 0.01, ***P < 0.001.