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. 2022 Jan 16;13(2):1963–1974. doi: 10.1080/21655979.2021.1995990

Figure 3.

Figure 3.

Circ_0048764 adsorbs miR-1296-5p (a) The potential binding site between circ_0048764 and miR-1296-5p was predicted by the Circinteractome database. (b) The interaction between circ_0048764 and miR-1296-5p was detected with a dual-luciferase reporter gene assay with HEK-293 T cells . (c) RIP assay was performed to detect the enrichment of circ_0048764 and miR-1296-5p in the immunoprecipitate of Ago2 group or IgG group. (d) qRT-PCR was used to detect the expression of miR-1296-5p in SKBR3 and MCF7 cells with circ_0048764 overexpression or knockdown. e and f. The expression of miR-1296-5p in BC tissues (e) and cell lines (f) was detected by qRT-PCR. (g) Pearson’s correlation analysis was performed to detect the correlation between circ_0048764 expression and miR-1296-5p expression in BC tissues. * P < 0.05, ** P < 0.01, and *** P < 0.001.