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. 2022 Feb 9;13(2):4481–4492. doi: 10.1080/21655979.2022.2032967

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Protective role of circCHFR-siRNA in ox-LDL-exposed HUVECs.

(A) The viability of HUVECs in the ox-LDL group was significantly decreased; (B–C). Apoptosis was significantly enhanced in the ox-LDL group; (D–F) Bax and Bcl-2 expression determined by Western blotting and qRT-PCR; (G–I) The secretion of cytokines in cell supernatants determined by ELISA kits. All experiments were repeated three times. **p < 0.01 vs. Control; ##p < 0.01 vs. ox-LDL+control-siRNA; &&p < 0.01 vs. ox-LDL+circCHFR-siRNA+inhibitor control.