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. 2022 Feb 3;13(2):4185–4200. doi: 10.1080/21655979.2022.2026727

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — CircPLK1 targets miR-1294. (a) Starbase predicted that CircPLK1 targeted miR-1294. (b) The expression level of miR-1294 was detected by qRT-PCR in circPLK1 overexpression cells. (c) Dual luciferase reporter assay using WT and mutated reporter. (d) The interaction between circPLK1 and miR-1294RNA pull-down assay. (e) Anti-Ago2 RIP assay, IgG isotype was used as negative control. (f) The expression level of miR-1294 in NSCLC cell lines was detected by qRT-PCR. (g) The expression level of miR-1294 in NSCLC and adjacent normal tissues was detected by qRT-PCR. (h) Spearman correlation coefficient was used to analyze the correlation between circPLK1 and miR-1294 expression in 50 NSCLC tissues. *P < 0.05; **P < 0.01; ***P < 0.001.