Figure 5.
TRIM21 inhibits tumorigenesis of OC in vivo. (a) The overexpression efficiency of TRIM21 in SKOV3 stable cells was detected. (b-d) 1 × 107 TRIM21 overexpressed or vector SKOV3 cells and Matrigel (Corning; 1:1 ratio) were subcutaneously injected into the abdominal flanks of each mice. n = 6 for each group. Tumor weight and volume were recorded to assess the effect of TRIM21 overexpressed SKOV3 cells on the xenograft model. (e) Representative images of IHC-based correlation between TRIM21, Ki-67, p21 expression in the tumor xenografts. (f) Quantification of TRIM21 staining intensity in xenograft tumors. (g-h) Ki-67 and p21 positive cells were quantified in xenograft tumors. *p < 0.05, **p < 0.01, ***p < 0.001.