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Silencing of TBK1 inhibited ECM degradation in OA mice. ACLT mice were infected with lentivirus shTBK1 or shNC. (a) TBK1 mRNA level was detected by qRT-PCR. (b) Safranin O-fast green staining and (c) OARSI score were used for elevating cartilage destruction. (d) Serum CTX-II and (e) COMP were analyzed by the corresponding ELISA kits. *p < 0.05.
