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. 2022 Feb 7;13(1):1872–1879. doi: 10.1080/21655979.2021.2018976

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Silencing of TBK1 inhibited ECM degradation in OA cell model. ATDC5 cells were treated with various doses of IL-1β for 12 h, after which (a) mRNA and (b) protein levels of TBK1 were analyzed by qRT-PCR and Western blotting, respectively. ATDC5 cells were transfected with siTBK1 or siNC and then stimulated with 10 ng/ml IL-1β for 12 h. (c) mRNA and (d) protein levels of TBK1 were detected by qRT-PCR and Western blotting, respectively.(e) matrix-degrading enzymes (ADAMTS-4, MMP3, MMP13), and (f) ECM-related molecules (SOX9, collagen II, aggrecan) were analyzed by Western blotting. *p < 0.05.