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Silencing of TBK1 regulated ECM degradation via the JAK/STAT signaling. ATDC5 cells were transfected with siTBK1, pcSTAT3 or both, and then stimulated with 10 ng/ml IL-1β for 12 h. (a) Western blotting analysis for testing the expression of total and phosphorylated form of STAT3. Expression of (b) matrix-degrading enzymes (ADAMTS-4, MMP3, MMP13), and (c) ECM-related molecules (SOX9, collagen II, aggrecan) were analyzed by Western blotting. *p < 0.05.
