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. 2022 Mar 1;36(5-6):368–389. doi: 10.1101/gad.349284.121

Figure 2.

Figure 2.

Divergent superenhancer landscapes are diagnostic of KMT2Ar-specific transcriptional vulnerabilities. (A) A study schematic depicting an integrative analysis of superenhancer landscapes and selective transcriptional dependencies to define the AML core regulatory circuitry (CRC). (B) Primary and PDX samples are hierarchically clustered using Pearson correlation of the scores of 4798 superenhancers recurrent in at least two samples. Superenhancers with the largest average score difference between KMT2Ar and non-KMT2Ar leukemias are selectively shown. (C) Samples of all types are plotted according to the superenhancer scores (4798 superenhancers recurrent in at least two samples) using t-distributed stochastic neighbor embedding (t-SNE). (D) Superenhancer-associated selective AML dependencies are ranked according to Pearson correlation between superenhancer scores and dependency. Core regulatory TFs are highlighted in red. (E) A differential plot of average superenhancer scores versus average dependency scores in KMT2Ar versus non-KMT2Ar cell lines.