Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 1;36(5-6):278–293. doi: 10.1101/gad.349431.122

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Hopkins et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 1. — Functions of BRCA1/2 in homologous recombination. The BRCA1–BARD1 complex is recruited to the DSB-flanking chromatin marked by H2A K15ub and H4 K20me0 (Becker et al. 2021; Hu et al. 2021). The BRCA1 at DSBs recruits PALB2–BRCA2 to promote the assembly of RAD51 filaments, which enables D-loop formation following the resection by MRE11-CtIP and EXO1 or MRE11-CtIP and DNA2.