Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 1;36(5-6):278–293. doi: 10.1101/gad.349431.122

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Hopkins et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 3. — Models for the selective killing of BRCA1/2-deficient cells by PARPi. (A) PARPi induces more ssDNA gaps in BRCA1/2-deficient cells, promoting RPA exhaustion and replication catastrophe. (B) PARPi induces ssDNA gaps during replication and prevents complete gap repair, allowing gaps to persist into the next cell cycle and generate DSBs upon collisions with replication forks. BRCA1/2-deficient cells fail to repair collapsed forks and mount a checkpoint response, leading to progressive accumulation of DSBs over multiple cell cycles and cell death.