Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Selective killing of BRCA1/2-deficient cells by different DDR targeted drugs. Both PARPi and REV1i render the ssDNA gaps in BRCA1/2-deficient cells persistent, promoting DSBs or replication catastrophe. POLθi blocks MMEJ and prevents alternative repair of DSBs in HR-defective cells, rendering DSBs persistent in BRCA1/2-deficient cells.
