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. 2022 Mar 1;36(5-6):241–258. doi: 10.1101/gad.349359.122

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© 2022 Sutherland et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Intratumoral heterogeneity and mechanisms of plasticity in SCLC. (Left) SCLC cells within individual human tumors are classified as NE-high (SCLC-A and SCLC-N subtypes) or non-NE SCLC (SCLC-Y and SCLC-P subtypes). Non-NE tumor cells are immunomodulatory and have an increased response to immune checkpoint blockade (ICB). (Top right) SCLC cells demonstrate subtype plasticity. SCLC-A cells can evolve to SCLC-N and SCLC-Y. It remains unknown whether (1) SCLC-P can evolve to or from the other subtypes or (2) non-NE cells can convert back to a NE-high phenotype. (Middle right) Molecular mechanisms implicated in driving NE to non-NE SCLC cell fate transition.