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Nintedanib inhibited the TNF-α-induced expression of pro-inflammatory cytokines such as IL-6 and IL-1β. Cells were stimulated with TNF-α (10 ng/mL) with or without Nintedanib (7.5, 15 μM) for 24 hours. (a). mRNA of IL-6 and IL-1β; (b). Secretions of IL-6 and IL-1β (####, P < 0.0001 vs. Vehicle group; **, ***, P < 0.01, 0.001 vs. TNF-α group).
