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Nintedanib restored the levels of PKA RI and p-CREB against TNF-α. Cells were stimulated with TNF-α (10 ng/mL) with or without Nintedanib (7.5, 15 μM) for 6 hours. (a). The expression of PKA RI; (b). The levels of p-CREB (####, P < 0.0001 vs. Vehicle group; **, ***, P < 0.01, 0.001 vs. TNF-α group).
