Table 4.

Relationships between mRNA expression levels of six targets and the clinicopathological parameters of cervical cancer patients

Parameters	Relative expression of CCNA2			Relative expression of CCND1			Relative expression of CCNE1			Relative expression of CDK2			Relative expression of CDK6			Relative expression of p21CIP1
	High	Low	P	High	Low	P	High	Low	P	High	Low	P	High	Low	P	High	Low	P
Age (n = 304)
≥60 years old	34	31	0.67	33	32	0.89	31	34	0.67	25	40	0.04*	27	38	0.12	33	32	0.89
<60 years old	118	121		119	120		121	118		127	112		125	114		119	120
Histological classification (n = 304)
Squamous cell cancer	130	122	0.22	133	119	0.03*	133	119	0.03*	137	115	<0.01**	146	106	<0.01**	144	108	<0.01**
Adenocarcinoma	22	30		19	33		19	33		15	37		6	46		8	44
Primary tumor (n = 241)
T1-T2	102	109	0.86	96	115	0.14	104	107	0.45	104	107	0.94	96	115	0.03*	104	107	0.15
T3-T4	15	15		18	12		17	13		15	15		20	10		19	11
Lymph node invasion (n = 193)
N0	64	69	0.65	61	72	0.59	63	70	0.93	67	66	0.36	61	72	0.34	65	68	0.32
N1	31	29		30	30		28	32		26	34		32	28		34	26
FIGO stage (n = 297)
Stage I–II	112	119	0.28	113	118	0.71	113	118	0.56	120	111	0.35	113	118	0.31	106	125	0.02*
Stage III–IV	37	29		34	32		35	31		30	36		37	29		41	25

Statistical analyses were performed using the chi-square test. *p < 0.05, **p < 0.01. Abbreviations: FIGO: Federation International of Gynecology and Obstetrics