TABLE 2.
Results of multivariable linear regression modeling sex by neuroinflammatory marker on global cognition
| Main effects of sex and neuroinflammatory marker level | Sex x neuroinflammatory marker interaction | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Outcome/neuro‐inflammatory marker | Sex (male vs. female) | Neuroinflammatory marker level | |||||||
| B, β | SE | P Value | B, β | SE | P Value | B, β | SE | P Value | |
| MMSE | |||||||||
| IL‐6 | ‐0.004, ‐0.020 | 0.012 | .736 | 0.002, 0.010 | 0.020 | .861 | –0.019, –0.168 | 0.020 | .323 |
| TNFα | ‐7.304e‐4, ‐0.004 | 0.001 | .953 | –0.004, –0.116 | 0.002 | .059 | 0.056, 0.192 | 0.036 | .122 |
| sTNFR2 | ‐0.028, ‐1.241 | 0.011 | .010 | –2.196e‐04, ‐0.471 | 6.153e‐5 | .009 | 2.327e‐04, 1.406 | 8.407e‐05 | .006 |
| YKL‐40 | 0.002, 0.100 | 0.002 | .314 | –1.325e‐04, ‐0.206 | 6.084e‐05 | .032 | 1.431e‐04, 0.373 | 1.201e‐04 | .237 |
| CDR‐SOB | |||||||||
| IL‐6 | 0.006, 0.004 | 0.077 | .941 | 0.022, 0.020 | 0.061 | .723 | 0.085, 0.116 | 0.123 | .492 |
| TNFα | 0.014, 0.011 | 0.077 | .857 | 0.091, 0.047 | 0.118 | .438 | 0.183, –0.099 | 0.227 | .421 |
| sTNFR2 | 1.470, 1.097 | 0.627 | .021 | 0.001, 0.431 | 4.260e‐4 | .005 | –0.001, –1.201 | 4.993e‐4 | .018 |
| YKL‐40 | 0.001, 0.308 | 6.785e‐4 | .051 | 0.397, 0.293 | 0.375 | .292 | –0.001, –0.438 | 8.785e‐4 | .175 |
Abbreviations: CDR‐SOB, Clinical Dementia Rating–Sum of Boxes; IL‐6, interleukin‐6; MCI, mild cognitive impairment; MMSE, Mini Mental State Examination; SE, standard error; sTNFR2, tumor necrosis factor receptor 2; TNFα, tumor necrosis factor α; YKL‐40, chitinase‐3‐like protein 1.