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. 2022 Mar 21;60(5):51. doi: 10.3892/ijo.2022.5341

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of ADAM12 on migration, invasion and the EMT-like phenotype in GC cells. (A) The diagram of ECM-receptor interaction signaling pathway. (B) ADAM12 overexpression enhances the migration and invasion ability in AGS cells (^*P<0.05, ^***P<0.001). (C) ADAM12 overexpression promotes the EMT-like phenotype in AGS cells. (D) ADAM12 knockdown interferes with the migration and invasion ability in HGC27 cells (^*P<0.05, ^***P<0.001). (E) ADAM12 knockdown inhibits the EMT-like phenotype in HGC27 cells. (F) Correlation coefficient circles for ADAM12 and EMT-related genes from the TIMER database. Pink lines represent positive correlations and blue lines represent negative correlations. ADAM12, a disintegrin and metalloprotease 12; GC, gastric cancer; EMT, epithelial-mesenchymal transition.