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. 2022 Mar 15;49(5):66. doi: 10.3892/ijmm.2022.5122

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Copyright: © Schott et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of histone inhibitor Chaetocin on Cyld^+/+ and Cyld^−/− melanoma cells. Representative (A) western blot of H3K9me2 and H3K9me3 levels following 24 h treatment with Chaetocin (10 nM) relative to H3 and (B) anchorage-dependent clonogenic assay of murine cell lines. Representative (C) western blot of H3K9me2 and H3K9me3 levels following 24 h treatment with Chaetocin (10 nM) relative to H3 and (D) anchorage-dependent clonogenic assay (hCyld^+/+:hCyld^−/− cell colony size). ^*P<0.05. CYLD, CYLD lysine 63 deubiquitinase; H3, histone 3; ctrl, control; m, mouse; h, human.