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. 2022 Mar 15;49(5):66. doi: 10.3892/ijmm.2022.5122

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Copyright: © Schott et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Model of CYLD deficiency in melanoma cells. The upregulation of EHMT2 and associated di-methylation of H3K9 leads to heterochromatin and the induction of proliferation of proliferation. CM272, which inhibits the activity of EHMT2. The associated decrease in H3K9me2 levels results in loosening of chromatin and decreased proliferation of CYLD-deficient melanoma cells (abstracted and modified from smart.servier.com/). EHMT2, euchromatic histone lysine methyltransferase 2; CYLD, CYLD lysine 63 deubiquitinase.