Figure 5.

Baze and SCH inhibit the expression of target genes downstream of the IL-6 and IL-8 pathways in human ovarian cancer cells. SKOV3 and CAOV3 cells were treated with DMSO, a single drug or their combination. The levels of p-STAT3, p-AKT, p-S6 and survivin were determined by western blot analysis. (A) CAOV3. (B) SKOV3. ^*P<0.05, ^**P<0.01, ^***P<0.001 and ^****P<0.0001 (DMSO vs. Baze, SCH or Baze + SCH). B+S, Baze + SCH; B10, BAZE 10 µM; B5, BAZE 5 µM; BAZE, Baze; S50, SCH 50 µM; p-phosphorylated; SCH, SCH.