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. 2022 Feb 13;13(3):4832–4843. doi: 10.1080/21655979.2022.2034586

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — LncRNA SNHG8 is activated by YY1

(A) The predicted sites of YY1-binding in lncRNA SNHG8 promoter were obtained from JASPAR.(B and C) RT-qPCR was used to measure YY1 expression in melanoma tissues and cells.(D) ChIP assay confirmed the enrichment of lncRNA SNHG8 promoter in the beads conjugated with anti-YY1 or anti-IgG.(E) Luciferase reporter assay revealed the interaction of YY1 with lncRNA SNHG8 promoter.(E) expression of YY1 was confirmed by RT-qPCR in A375 and A875 cells transfected with shYY1, shNC, pcDNA3.1 or pcDNA3.1/YY1.(G) RT-qPCR showed the level of lncRNA SNHG8 after the overexpression or knockdown of YY1.*P < 0.05; **P < 0.01;***P < 0.001