Figure 1.

circCDK6 is upregulated in the four cervical cancer cell lines. A. the circCDK6 expression showed a significant upregulation in the cervical cells. B. the transcript half-life of circCDK6 in CaSki and Hela cells treated with transcription inhibitor Actinomycin D. C. RNase R was administrated to the extracted RNA to measure the relative expression of circular form (circCDK6) and its linear form in CaSki and Hela cells. D. the subcellular distribution of circCDK6 was detected using CaSki and Hela cells. The circCDK6 and the nucleus showed as red blue, respectively. The scale bar is 100 μm. *p < 0.05, **p < 0.01 and ***p < 0.001 vs. respective control.