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Knockdown of circRNA_0000258 regulates HeLa cell viability and apoptosis via upregulation of miR-654-3p expression. HeLa cells were transfected with control-siRNA, circ-siRNA, inhibitor control or miR-654-3p inhibitor. (a) Cell viability assessed using MTT assay. (b, c) Flow cytometry analysis of apoptotic cells. (d) Expression of Bax and Bcl-2 detected using Western blotting. (e) Ratio of Bax/Bcl-2. P < 0.05, **P < 0.01 vs. control.
