Figure 4.

miR-129-5p affected cardiac function in CHF rats through Smurf1. A-B: The levels of Smurf1 in myocardial tissue of rats detected by qRT-PCR and WB; C: The ratios of heart weight/body weight, left ventricle weight/body weight, and lung weight/body weight were measured; D: Histopathological changes of the myocardium observed by HE staining; E: Masson staining observed the degree of myocardial tissue fibrosis; F: The levels of SOD, GSH-Px and MDA detected by ELISA; N = 10; Values in the figure were measurement data and displayed as mean ± standard deviation. Unpaired t test was used for pairwise comparisons; one-way ANOVA was used for comparisons among multiple groups, followed by Tukey’s test. * P < 0.05.