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Memantine mitigated oxaliplatin-induced alteration in the ratio of Bax/Bcl-2. Cells were treated with oxaliplatin at 50 μM and Memantine at 5 and 10 µM for 24 hours. (a). Protein expression of Bax and Bcl-2; (b). Statistical analysis of Bax/Bcl-2 (n = 5, **, P < 0.01 vs. vehicle group; #, ##, P < 0.05, 0.01 vs. oxaliplatin group).
