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Downregulation of SPAG5 declined the expression of ADAM17, NOTCH1 and HES1 in MM cells. (a) Western blotting was used to detect the expression of ADAM17, NOTCH1 and HES1 in A375 and A2058 cells transfected with shNC, shSPAG5-1 and shSPAG5-2. (b) Western blotting was used to detect the expression of ADAM17, NOTCH1 and HES1 in A375 and A2058 cells transfected with shNC+NC, shSPAG5-2+ NC and shSPAG5-2+ ADAM17. (n = 3, *P < 0.05, **P < 0.01; NC, negative control).
