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. 2022 Feb 9;13(3):4744–4756. doi: 10.1080/21655979.2022.2031670

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Downregulation of SPAG5 decreased the expression of ADAM17, HES1 and NOTCH1 through downregulation of FOXM1 in MM. (a) SPAG5 downregulation on the expression of FOXM1 was determined by Western blotting. (b)The expression of FOXM1, ADAM17, HES1 and NOTCH1 were detected by Western blotting in A375 and A2058 cells with FOXM1 overexpression or without. (c) Western blotting was used to detect the expression of FOXM1, ADAM17, NOTCH1 and HES1 in A375 and A2058 cells transfected with shNC+NC, shSPAG5-2+ NC and shSPAG5-2+ FOXM1. (n = 3, *P < 0.05, **P < 0.01; NC, negative control).