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Downregulation of SPAG5 weakened the in vivo tumor formation ability of A375 cells. (a) Tumor volume and weight. (b) The expression of SPAG5, FOXM1, ADAM17, NOTCH1, E-cadherin and N-cadherin in shNC and shSPAG5-2 groups were detected using IHC. (c) Hematoxylin eosin staining was used to assess the lung metastasis of MM (Each group had 5 mice, **P < 0.01).
