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. 2022 Feb 10;13(2):4557–4572. doi: 10.1080/21655979.2022.2029236

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Cilengitide potentiates anti-PD1 antibody efficacy by activating CD8⁺ T cell response. (a) Representative images of immunofluorescence staining of CD3, CD4 and CD8 in tumors (n = 3). Scale bar: 100 µm. (b and c) Quantified results of CD4⁺ and CD8⁺ cells in tumors. (d) The contents of granzyme B in tumors determined by ELISA (n = 4). (e) The contents of IFN-γ in tumors determined by ELISA (n = 4). Data were represented as mean ± standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001, NS, not significance (Student’s t test).