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. 2022 Jan 19;13(2):2866–2877. doi: 10.1080/21655979.2021.2024970

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — 4-PBA attenuated the suppression of MRP2 by RFP.

HepG2 cells were treated by RFP (50 uM) and/or 4-PBA (1 mM) for 48 h. (a and b) mRNA and protein expression of MRP2 were detected through qRT-PCR assay and Western blotting, respectively. (c) Immunofluorescence assay was carried out to further test MRP2 expression. (d) The ubiquitination of MRP2 was checked by in vitro ubiquitination assay. (e) The protein level of GP78 was evaluated via Western blotting. ***P< 0.001 vs. control group; ^#P< 0.05, ^###P< 0.001 vs. RFP group; ^&P< 0.05, ^&&P< 0.01 vs. 4-PBA group.