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. 2022 Jan 19;13(2):2866–2877. doi: 10.1080/21655979.2021.2024970

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — 4-PBA protected mice against RFP-induced cholestatic liver injury.

RFP-induced cholestasis mouse model was established and treated by 4-PBA. (a) Serum bilirubin concentration was tested vi ELISA. (b) The protein expression of MRP2 in liver tissues was measured via Western blotting. (c) The ubiquitination of MRP2 in liver tissues was tested via ubiquitination assay. (d) The protein levels of GRP78 BIP, CHOP, Cleaved-Caspase-12, Cleaved-Caspase-3, PERK, ATF6, XBP-1, IRE-1, p-JNK and p-p38 in liver tissues were evaluated via Western blotting. *P< 0.05, **P< 0.01, ***P< 0.001 vs. control group; ^#P< 0.05, ^##P< 0.01 vs. RFP group.